ilgis

**
Posts: 18
Joined: August 30, 2016
Group: Administrators

June 5, 2017 @ 1:56 PM
Hi,

we expect to deliver first devices in about one month, hence, right now we are open for your kind pre-sales questions.

Dimensions

The Elegant NMR Stick is a small device. The probe has a diameter of one inch, a length of 10 inches, and a weight of about one pound. The upper PTFE part is suitable for standard NS29 ground glass joint - a standard chemical vessel or reactor glassware.

The measurement area of the Elegant NMR Stick is small, and the following list provides estimates of the amounts of liquids required to make measurements:

injecting liquids over the flow connectors requires only 1 ml

placing the stick into a 30-mm diameter vessel requires only 10 ml

the smallest vessel with an NS29 joint requires 100 ml

measurements in a standard 3-4-joint vessels require at least 200 ml.


The Elegant NMR Stick mainly was designed for low-viscosity liquids, but high-viscosity liquids and even liquids with particles can be measured. The size of the internal measurement area was designed and constructed to prevent fouling, but if fouling occurs, the measurement area must be cleaned to obtain correct results. All of the walls of the measurement area are coated with PTFE, so cleaning is simple.

Caution! Please, be as careful as possible when cleaning the internal measurement area because sharp metal parts can cause irreversible damage to the spectrometer. Start the calibration procedure after cleaning!

Materials

The Elegant NMR Stick is made of stainless steel coated with PTFE. There are only a few exceptions concerning the environment in which it can be used, one of which is fluorine, which dissolves PTFE.

All components of the Elegant NMR Stick are constructed with normal materials, conforming to the requirements of ROHS and CE. No radioactive components, ionization components, high pressure gases or liquids, high voltage, or poisonous chemicals are used in the device.

Caution! Only the lower area below NS29 joint is covered by PTFE and compatible with substances from the list. The upper area should be protected carefully from external heat and aggressive substances. We recommend that water be used to keep the device cool during operation as is done for cooling copper, zinc, or tin devices, e.g., radiators.

Caution! The Elegant NMR Stick is incompatible with magnetic stirring or moving metal and magnetic parts in close proximity to the device; only non-metal and non-magnetic mechanical stirrers should be used, i.e., glass or PTFE stirrers.

Temperature range

There are rare earth magnets inside the device, and they can be used for temperatures up to 480F/250C. In any situations and temperature ranges liquid cooling/heating for the electronics through cooling connectors is always recommended/required.

The flow rate in the cooling connectors is highly dependent on the temperature in the measurement area, and it must reach 1 l/min for high-temperature conditions. The pressure of the cooling liquid should always be in the range of 0.1 bar. These are standard conditions for most liquid cooing glassware, which generally is available in any chemical laboratory.

The Elegant NMR Stick has several thermosensors and fuses. The thermosensors will indicate when the device is approaching its temperature limits, and, if the internal temperature exceeds the upper limit of the range, fuses will break irreversibly to stop the operation of the Elegant NMR Stick.

Our warranty is voided if the temperature-sensing fuses are broken on the device! Repair is difficult at best, and it usually is impossible, so we strongly recommend that users avoid working without liquid conditioning.

Power and data connectivity

The Elegant NMR Stick requires about 5 V USB bus and 15V/3A wall power.

Several Elegant NMR Sticks connected to one computer can work simultaneously to get better resolution of the spectra and concentrations.

There is no limit to the number of Elegant NMR Sticks that can operate simultaneously. The only limitations are the number of USB connections that are available and the power required. Usually, data flow is below 100 KB/s, however spectra are stored in local disk situated on the stick, and user may require to copy it with USB2.0 data speed rate.

Software

The software license for end-user GUI applications is free, and our software can be installed in any computer to start processing. The software is not restricted to one Stick or only the Sticks that have been purchased. The software can be used with any Elegant NMR Sticks, e.g., those borrowed from colleagues.

There is proprietary firmware inside the Stick, and we provide a method to update this firmware free of charge for our customers.

The Elegant NMR Stick uses an internal format of Free Induction Decays, which makes it capable of supporting non-uniform, multi-dimensional sampling. Projections to one-dimensional and multi-dimensional NMR spectra can be stored in the ASCII format. The reason why we do not store our FIDs in general formats stay in the fact that we use special preprocessing that is described on https://arxiv.org/abs/1706.00237 that require to link several FIDs together with reference FID data together, including non-uniform sampling.

Miscellaneous questions

Q: What is NMR?

A:
The physical phenomenon of Nuclear Magnetic Resonance (NMR) is rather complicated. The basic idea is that it is what happens when an atom is placed in a magnetic field, where it absorbs and then re-emits electromagnetic waves. A very good description of this can be found in Wikipedia.

Generally, each chemical substance has its own unique NMR spectrum, which depends on the presence of certain isotopes, the so-called non-zero spin isotopes. Many chemical elements found in nature have a large percentage of non-zero spin isotopes. Thus, they appear on the NMR spectrum. Besides the number of these isotopes, the NMR spectrum is also dependent on the intensities of the resonance. Both of these quantities are well known, and they are available in reference tables. (See, for example, this table.

Q: Can the Elegant NMR Stick provide the NMR spectra of gases?

A:
Gas measurement by the Elegant NMR Stick is straightforward, however the resolution of the NMR of a gas usually not as high as those for liquids. Hence, only large concentrations of organic vapors can be detected, but there are many exceptions. For example, we cannot \"see\" oxygen in air because oxygen mainly contains the zero-spin isotope 16O. Gases of organic substances can be detected starting from concentrations of about the 100mmol/l level, which is about 0.2% in volume. Usually, about 10% concentration is required to detect what the substance is. This scientific fact restricts making gas measurements by the Elegant NMR Stick.

Q: Can the Elegant NMR Stick provide NMR spectra of solid state matter?

A:
The Elegant NMR Stick is not designed for solid state experiments. However, if the solid material will fit a quartz tube that is 0.1 inch diameter, it is possible to get the NMR spectrum, but this is not a standard application for this device, and the accuracy of measurement cannot be predicted.

Q: You stated that there is a flow sensor inside the Elegant NMR Stick. How is that possible?

A:
The Elegant NMR Stick incorporates several coils and performs some type of MRI, providing 2D flow rate. In case the flow rate is very high, degradation of the accuracy of the chemical composition and the spectra is likely to occur, especially if the liquid being investigated is not homogeneous. On the video and in the picture where three sensors are working simultaneously, it is apparent that the spectra corresponding to flow matter are smoother than the others.

Q: The magnets in the Elegant NMR Stick are small and probably deliver a non-homogeneous magnetic field; how does this affect the accuracy of the measurements?

A:
It is difficult to make a highly-homogeneous magnetic field using 1-inch diameter magnets. However, we have several transmitting and receiving coils and a numerical algorithm that computes the correlation and produces the results as if the sample were situated in a highly-homogeneous field.

Q: Is the Elegant NMR Stick suitable for teaching purposes?

A:
In teaching, you probably would want to consider one-dimensional projections of multi-dimensional spectra, i.e., slices of 1H spectra, because they refer to different parts of molecules. It would help students become interested in spectra and NMR spectrometry itself, resulting in their considering NMR spectra as being far more than complicated, meaningless graphs. It is very important for the low-field situation (as is the case for our device), because different groups overlap a lot and cannot be distinguished as on 600-900 MHz devices. Indeed, 600-900 MHz, multi-dimensional spectra are more beautiful, but the devices that provide them are quite heavy and probably not suitable for student practicum.
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